DDIT4 and obesity due to melanocortin 4 receptor deficiency: In another study, loss of METTL3 leads to a reduction in the activity of mTOR and NF-κB signaling pathways, resulting from the stabilization of m6A-mediated DNA Damage Inducible Transcript 4 (DDIT4) mRNA in macrophages, which regulated metabolic reprogramming in NAFLD and obesity [64].