PKM and hepatocellular carcinoma: In HCC, it has been found that multiple molecules involved in the multi-step process of glucose metabolism are abnormally expressed in HCC, which is an adverse prognostic factor of liver cancer, including GLUT1 (Amann and Hellerbrand 2009), PKM2 (Liu et al. 2017), and HK2 (DeWaal et al. 2018).