Protein-protein network analysis demonstrated that ANXA1 interacts directly with genes enriched for asthma (including IL4 and IL13) and inflammatory regulation (NR3C1, glucocorticoid receptor) showing its significance in dysregulation of the immune response (see Appendix 5—figure 2 and Appendix 5—table 5). This evidence concerns the gene NR3C1 and asthma.