ACOXL and obesity due to melanocortin 4 receptor deficiency: Several genes/loci identified as top hits for late-onset wheeze were previously associated with asthma: ACOXL chr2q13 (later onset asthma and obesity; Zhu et al., 2020), PRKAA2 chr1p32.2 (lymphocyte count and asthma susceptibility; Cusanovich et al., 2012), CD200 3q13.2 (adult onset non-allergic asthma; Siroux et al., 2014), GIMAP family 7q36.1 (autoimmune diabetes, asthma, allergy; Heinonen et al., 2015), 9p22.3 (asthma in <16 years of age; Denham et al., 2008), and 16p12.1 (asthma and rhino-conjunctivitis at 10–15 years; Sottile et al., 2019).