SERPING1 and hereditary angioedema: SC C1‐INH or lanadelumab should be used as first‐line therapy for LTP of HAE attacks.Attenuated androgens and antifibrinolytics should not be used as a first‐line therapy for LTP of HAE attacks, but they may be considered in patients who have already obtained benefit from their use or who have difficulty obtaining first‐line options.