IV pd‐C1‐INH and icatibant (in patients aged >2 years) are the first‐line on‐demand treatments.Plasma is a second‐line STP treatment.For treatment of HAE attacks in patients aged <12 years, icatibant may be used in patients aged >2 years; IV pdC1‐INH and FFP can be used without age restrictions. The gene discussed is SERPING1; the disease is hereditary angioedema.