SERPING1 and hereditary angioedema: IV C1‐INH, ecallantide, or icatibant are recommended as first‐line therapies for on‐demand treatment of HAE attacks.Where first‐line therapies are not available, attacks should be treated with SDP.If SDP is not available, attacks should be treated with FFP where safe supply is available.Use of antifibrinolytics or androgens for on‐demand treatment of HAE attacks is advised against.