To test if mTOR activation may play a role in the augmented susceptibility of HTR8 cells to ZIKV infections, the dependency of the ZIKV strains’ replication on the activation of the mTOR pathways was evaluated using rapamycin and AZD8055, two allosteric inhibitors of the mTOR pathways (34, 35). The gene discussed is MTOR; the disease is Zika virus infectious disease.