The Cdc42 sensor dimericTomato–WASp(CRIB) accumulated in a spatially restricted manner upon invadopodia formation induced by phorbol ester phorbol 12,13-dibutyrate (PDBu) treatment of SUM159 breast cancer cells (Fig. 7C; Fig. S5F, Movies 5, 6). The gene discussed is CDC42; the disease is breast carcinoma.