A positive correlation between the Cornell score for depression severity in dementia (Alexopoulos, Abrams, Young, & Shamoian, 1988) and the number of CRH-expressing neurons in the PVN has been found earlier (Meynen, Unmehopa, Hofman, Swaab, & Hoogendijk, 2007). This evidence concerns the gene CRH and major depressive disorder.