S100A8 and psoriasis: Interesting additional hits, most probably masked in the total skin profiling, were (i) the upregulation of S100A8 and 9, strong inflammatory modulators, described to be the most upregulated proteins in psoriatic epidermis (Schonthaler et al, 2013; Wang et al, 2018) and (ii) Defb1, an antimicrobial peptide, highly upregulated in psoriasis with a strong genomic association between its increased gene copy number and the risk of psoriasis (de Jongh et al, 2005; Hollox et al, 2008).