Known inducers of ILEI translation and secretory activity, such as TGFβ, uPA, and uPAR, showed at the same time significantly elevated expression in the same datasets (Fig EV1E and F), being in accordance with earlier reports (Han et al, 2010; Rubina et al, 2017) and indicating an upregulation of the ILEI translational and secretory machinery in psoriasis. The gene discussed is PLAU; the disease is psoriasis.