Mechanistically, TOPK was found to mediate hypoxia‐induced epithelial‐mesenchymal transition (EMT) and the invasion of NSCLC cells via the HIF‐1a/snail axis,17 and promote the EMT and invasion of breast cancer cells by upregulating TBX3 in TGF‐β1/Smad signalling.10 This evidence concerns the gene HIF1A and non-small cell lung carcinoma.