Previous studies showed that KRASG12C mutation induces the abnormal activation of various signalling pathways such as PI3K/Akt, MAPK/ERK and RALGDS/RAL7 and the hyper‐activation of transcription factors including Elk1 and NF‐κB,25, 31, 32 which are essential oncogenic signals for the tumorigenesis and tumour progression. This evidence concerns the gene AKT1 and neoplasm.