Previous studies showed that KRASG12C mutation induces the abnormal activation of various signalling pathways such as PI3K/Akt, MAPK/ERK and RALGDS/RAL7 and the hyper‐activation of transcription factors including Elk1 and NF‐κB,25, 31, 32 which are essential oncogenic signals for the tumorigenesis and tumour progression. The gene discussed is ELK1; the disease is neoplasm.