There was a significant difference in marital status, ethnicity, BMI, β‐blocker, ACEI, ARB, diuretics, hypertension, COPD, AF, respiratory rate, heart rate, SBP, DBP, hemoglobin, neutrophil, lymphocytes, albumin, BUN, creatinine, creatine kinase, potassium, sodium, pH, lactate, glucose, PO2, PCO2, BE, GCS, OASIS, SAPS, and SOFA among the groups divided by L/A ratio. The gene discussed is ALB; the disease is chronic obstructive pulmonary disease.