CD274 and neoplasm: Besides, lower RSI is also correlated with higher RNA stemness score, indicating higher degrees of stemness and tumor de-differentiation, which is also related to increased PD-L1 protein expression [79].To further explore the relationship between RSI and immune response, a team used whole transcriptomic and matched proteomic data from 12,832 primary and 585 metastatic tumors and found that RSI was associated with a variety of immune-related genomic and molecular features.