A similar regulation of Dnm3os was observed in macrophages from high-fat diet-induced insulin-resistant mice, streptozotocin (STZ)-induced type 1 diabetic mice, and STZ-induced diabetic apolipoprotein E deficient mice (a model of accelerated atherosclerosis) compared with controls (Fig. 3a). The gene discussed is DNM3OS; the disease is atherosclerosis.