In contrast, Nguyen et al. did not show any significant differences in Ca2+ influx through TRPM3 in ME/CFS patients compared to HC; however, this was potentially due to interfering small inward currents activated by PregS through the flow cytometry technique which was not apparent in the confocal microscopy approach [83]. The gene discussed is TRPM3; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.