Hardcastle et al. reported that moderate ME/CFS patients had significantly increased CD8+CD45RA effector memory T cells, signalling lymphocytic activation molecule expression on NK cells, killer cell immunoglobulin-like receptor 2DL5A on CD4+ T cells, and BTLA4+ on CD4+ T central memory cells [50]. This evidence concerns the gene CD4 and myalgic encephalomeyelitis/chronic fatigue syndrome.