ADAMTS13 and endometriosis: The findings highlighted that the negative causal effects of the genetically predicted plasma ADAMTS13 level on the risk of endometriosis remained significant with a large effect size (IVW: OR = 0.46, 95%CI: 0.30–0.71, P = 5.31e − 4; WM: OR = 0.53, 95%CI: 0.33–0.85, P = 0.009), which was consistent with the findings from the UK Biobank (Fig. 2B, Additional file 1: Table S4, Additional file 2: Fig. S3).