The significant MR result of vWF on the risk of endometriosis was also observed (IVW: OR = 1.26, 95%CI: 1.09–1.46, P = 0.002; WM: OR = 1.29, 95%CI: 1.10–1.51, P = 0.002) (Fig. 3, Additional file 1: Table S6, Additional file 2: Fig. S5). This evidence concerns the gene VWF and endometriosis.