The results also showed that the genetically predicted plasma vWF level was positively causally associated with the risk of endometriosis (IVW: OR = 1.28, 95%CI: 1.06–1.53, P = 0.009; WM: OR = 1.33, 95%CI: 1.08–1.62, P = 0.006), although the effect may not remain significant after adjusting for multiple comparisons (Fig. 2B, Additional file 1: Table S4, Additional file 2: Fig. S3). The gene discussed is VWF; the disease is endometriosis.