Heterogeneity tests revealed heterogeneity in endometriosis for three coagulation factors, vWF (IVW: Cochran’s Q = 20.35, Pheterogeneity = 0.041), aPTT (IVW: Cochran’s Q = 16.57, Pheterogeneity = 0.011), and FVIII (IVW: Cochran’s Q = 11.80, Pheterogeneity = 0.003) (Additional file 1: Table S2). This evidence concerns the gene F8 and endometriosis.