CASP8 and cancer: The promising cytotoxic effect against liver carcinoma can be well correlated with the tentatively identified phenolic compounds where caffeic and gallic acid was reported to reduce the growth of MCF-7 breast cancer cells and altered the expression of apoptotic genes [97], ferulic acid also promotes apoptosis in cancer cell lines MCF-7 and HepG-2 and activated the caspase-8 and − 9 pathways, has cytotoxic action and [98].