TP53 and cancer: T.nilotica has been previously reported for promising cytotoxic activity against human colon (HCT-116) and breast (MCF-7) cancer cells [94], whereas ethyl acetate was active against lung cancer cell line with increased expression levels of p-53 and Bax whereas that of Bcl-2 was decreased [36, 37], while flowers were effective and selective against liver cell carcinoma (Huh-7) [38].