In the CheckMate 040 study [34], the ORR of PD-L1-positive patients was 26% in PD-L1-positive patients and 19% in negative patients, suggesting that negative expression of PD-L1 on tumor cells had no significant difference in the ORR against PD-1 therapy compared with PD-L1-positive patients. Here, CD274 is linked to neoplasm.