TGFB1 and Loeys-Dietz syndrome: Mutations in genes associated with the transforming growth factor-β (TGF-β) signaling pathway can cause syndromic Thoracic Aortic Dissections (TAAD), such as Marfan syndrome (MFS), Loeys-Dietz syndrome (LDS), and Shprintzen-Goldberg Syndrome (SGS), which can potentially affect the cardiovascular system [3, 4].