Based on our findings, we propose a model (Fig. 8) whereby highly metastatic clones can co-opt (through TGF-β1 signalling) weakly or non-metastatic clones into expressing increased metastatic features, which in turn will enhance the invasion ability of the former (through released proteases and/or extracellular matrix remodelling)—i.e., a “help me help you” strategy, and ultimately result in an increase in the overall invasion potential of the tumour. This evidence concerns the gene TGFB1 and neoplasm.