With this in mind, our purpose was to examine the association between obesity, relative STL, mRNA expression of autophagy-related genes (Beclin1, AMPKa1, ULK1, BAX, and BCL2), values of semen parameters, sperm DNA integrity, chromatin maturation, apoptotic changes, and intracellular ROS levels. This evidence concerns the gene PRKAA1 and obesity due to melanocortin 4 receptor deficiency.