Of the enriched gene set (BRCA1, CCNE2, CDCA5, CDKN2A, E2F1, E2F2, KIF23, SOX4, TGFB2, TRIM71; 10/202 of hsa06206), breast cancer type 1 susceptibility protein BRCA1 specifically mediates the formation of Lys-6-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage, E3 ubiquitin-protein ligase TRIM71 can behave the post-transcriptional mRNA repression in a miRNA independent mechanism. The gene discussed is CDKN2A; the disease is cancer.