IRAK4 and systemic lupus erythematosus: Both interleukin-1 receptor-associated kinase 4 (IRAK4) and Toll-like receptor 7 (TLR7) were ranked from the top-10000 to the top-1000 genes for SLE before the first publication implicating them in the pathology of lupus, in 2009 by Cohen37 and 2005 by Barrat et al.38, respectively.