PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The genome-wide rankings for the human protein-coding genes PNPLA3, FGF21, and ANGPTL3 (Fig. 1B) rapidly increased before the first publications relating them to NAFLD: PNPLA3 by Romeo et al.27 in 2008 and FGF21 by Inagaki et al.28 and ANGPTL3 by Yilmaz et al.29 in 2007 (Fig. 1B).