Both interleukin-1 receptor-associated kinase 4 (IRAK4) and Toll-like receptor 7 (TLR7) were ranked from the top-10000 to the top-1000 genes for SLE before the first publication implicating them in the pathology of lupus, in 2009 by Cohen37 and 2005 by Barrat et al.38, respectively. Here, TLR7 is linked to systemic lupus erythematosus.