AKT1 and ischemic cardiomyopathy: From our perspective, PHLDA1 acts as an acute response protein in response to DOXO-injury to promote apoptosis through inhibition of Akt, which is consistent with several previous studies, such as elevated expression of PHLDA1 in rat ischemic cardiomyopathy model and in H9C2 cells cultured under hypoxia condition [45].