PTEN and cancer: The PTEN C-terminal tail is an intriguing domain in that it is rarely mutated in human cancers (https://cancer.sanger.ac.uk/cosmic), albeit, according to in vitro studies, implicated in the regulation of key PTEN properties linked to tumor suppression, including PTEN stability, localization, phosphatase activity, and homo- and heterotypic protein interactions12,14,31,33,36–38.