We therefore stratified TGCA gastric tumors based on PDZK1 mRNA levels into PDZK1 low (bottom 15%) and PDZK1 high (top 15%) cohorts, compared these two groups for differentially expressed genes, and then performed an overrepresentation analysis for target genes of LEF1, a β-catenin-dependent transcription factor associated with both gastric and prostate cancer progression52,53. The gene discussed is LEF1; the disease is Familial prostate cancer.