Lymphadenopathy was not observed in C-tail mutant mice which allowed for complementary assessment at 16 months for tumors with longer latencies, but again there were no differences in tumorigenesis between PtenS380A/A, PtenΔ4/Δ4 and Pten+/+ mice (Fig. 2d,e). This evidence concerns the gene PTEN and Lymphadenopathy.