Also, given the mounting evidence for pro-tumorigenic effects of PTEN C-tail phosphorylation, it will be interesting to further explore the therapeutic relevance of CK2 inhibitors such as CX-4945 (Silmitasertib) for the treatment of gastric cancers and other malignancies characterized by CK2 overexpression and elevated PTEN-C-tail phosphorylation65. Here, PTEN is linked to gastric cancer.