PTEN and cancer: These findings, together with data from studies in cancer cell lines showing that PTEN interacts with β-catenin and inhibits its nuclear accumulation and transcriptional activity50,51, led us to speculate that increased nuclear β-catenin in prostate epithelium of PtenS380D/D mice is due to aberrant PTEN-β-catenin interaction and a driver of PIN lesion formation.