The forced expression of PABPC1 was found to promote EMT and enhance cell invasion and migration; however, depleted PAK1 in the background of PABPC1 transfection in cells was found to reverse PABPC1-induced GC invasion and metastasis through EMT (Fig. 7G–L, Supplementary Fig. 8E–I). Here, PAK1 is linked to gastric cancer.