The Alzheimer Association has specifically highlighted the need for studies on the influence of kidney disease on the diagnostic performance of P-NfL as one of the top research priorities in its recent statement paper on the use of blood-based biomarkers.24 The aim of this study was to investigate kidney function associations with P-NfL and several other markers of neurodegeneration in individuals with and without CKD. The gene discussed is NEFL; the disease is kidney disorder.