Within the large interactome of 14-3-3 are many well-known disease-related proteins such as the Raf kinases (cancer), LRRK2 (Parkinson’s), and CFTR (cystic fibrosis), which make 14-3-3 proteins highly involved in a larger variety of cellular processes and which makes 14-3-3 protein complexes highly interesting as drug discovery targets (29). This evidence concerns the gene YWHAQ and cystic fibrosis.