Additionally, we found that treatment of the HepG2 cells with the CCDC80 recombinant protein significantly decreased the expression of the fatty acid metabolism transcription factor, PPARA,14,15 and treatment with the SOD3 recombinant protein significantly decreased the expression of the steatosis-associated gene, RNF128. 16We also demonstrated a possible adipose-origin unidirectional effect of serum triglycerides (TGs) on NAFLD in MR. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.