Taken together with the previously published NAFLD-related evidence for these three genes (see Discussion) our results suggest that the CCDC80 protein may induce hepatocytes to accumulate fat, while the SOD3 protein may promote healthy lipid metabolism in hepatocytes, in line with the observed increased (CCDC80) and decreased (SOD3) adipose expression in individuals with NAFLD (Fig. 2). This evidence concerns the gene SOD3 and metabolic dysfunction-associated steatotic liver disease.