LEP and metabolic dysfunction-associated steatotic liver disease: This was supported first by the observation that SOD3 adipose expression is decreased in individuals with NAFLD compared to those with healthy livers (Fig. 2, Supplementary Table S8), and second, by the observation that the knockdown of SOD3 during adipogenesis significantly decreased the expression of the satiety signalling protein LEP at 4 days (logFC = −0.651, p = 1.966 × 10−4vs control by R package limma) (Fig. 5c and d, Supplementary Table S12).