In line with these previous findings and our own adipose tissue CCDC80 NAFLD DE and CCDC80 knockdown results, we observed a significant downregulation of PPARA, NFE2L2, MOGAT1, and ZNF638 in the CCDC80 treated liver HepG2 cells when compared to the control cells. Here, CCDC80 is linked to metabolic dysfunction-associated steatotic liver disease.