TNF and dental caries: All markers are also important to development the specific immune responses.9 IL-1β and TNF-α have both been considered essential mediators of acute inflammation.5 Our current study aims to assess the levels of secretory IgA (s-IgA) and IL-1β in smokers with dental caries, knowing the correlation between these parameters and caries disease, as well as knowing the relationship between these two parameters in the same patients.