All markers are also important to development the specific immune responses.9 IL-1β and TNF-α have both been considered essential mediators of acute inflammation.5 Our current study aims to assess the levels of secretory IgA (s-IgA) and IL-1β in smokers with dental caries, knowing the correlation between these parameters and caries disease, as well as knowing the relationship between these two parameters in the same patients. This evidence concerns the gene IL1B and dental caries.