In innate responses, the molecular phenotypes associated with the oral pathogen bind to host cell receptors, including dendritic cells that have a role in activating the acute inflammatory response by releasing active pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.7 On the other hand, in cases where periodontitis develops with potent inflammatory responses, gingivitis will disappear, whereas if infection persists and bacterial proliferation occurs, intensification of the warning response can damage periodontal tissues in the affected patients.13 The gene discussed is TNF; the disease is periodontitis.