NFKB1 and plasma cell myeloma: Elevation of PIM2 reveals an anti-apoptotic function, which can be blocked by NF-κB inhibitor on multiple myeloma or lymphoma [[23], [24], [25]] and PIM2 knockdown mice model of gastric cancer augmented apoptosis and diminished the proliferation of cells by high levels of ROS induced by PIM2 silence [26].