Integrin β6 deficient (ITGB6-knockout) and wild-type (WT) mice were subsequently used to construct dextran sodium sulfate (DSS)-induced acute colitis mouse model and azoxymethane (AOM)/DSS-induced CAC mouse model to explore the role of integrin β6 in IBD and CAC. This evidence concerns the gene ITGB6 and inflammatory bowel disease.