IDH1 and central nervous system cancer: Figure 2A was derived from a 40-year-old female patient who suffered from intermediate headache and post-surgical pathology indicated that the right fontal lesion was an IDH wild-type GBM (glioblastoma, WHO grade 4). On the other hand, lesion in Figure 2B was a left temporal low-grade glioma from a 42-year-old female and she was diagnosed as IDH mutant astrocytoma (WHO grade 2). It can be observed that the APT% in the lesion of IDH wild-type (Figure 2A) is much higher than which of IDH mutant lesion (Figure 2B).