It has been demonstrated that in the presence of an apoptotic stimulus, mitochondrial survivin is released to the cytosol, (60) where it inhibits the activation of caspase-3 through its interaction with XIAP to continue proliferating (61); metformin decreases XIAP expression in colorectal cancer by STAT3 suppression (47). The gene discussed is BIRC5; the disease is colorectal cancer.