In patients with RDs, meta-analyses of randomized controlled trials (RCTs) indicate that oral nutrient supplementation (ONS) with probiotics resulted in an improvement in c-reactive protein (CRP) levels97 -with combined Bifidobacteriales and Lactobacillales formulations inducing the greatest response98-, an improved quality of life (Lactobacillales-only formulations),98 and a reduction in pain.98 On the other hand, as far as patients with psoriasis are concerned,99 probiotics ONS appears to improve psoriasis area and severity index (PASI) score. Here, CRP is linked to psoriasis.