A recent systematic review indicated that in RA, ONS with curcumin (doses of 250–1500 mg/day) over 8–12 weeks is associated with a reduction in ESR and decreases in CRP concentrations.103 When a greater duration of supplementation (> 8 weeks) is adopted, paired with a large curcumin dosage (> 500 mg), the observed reductions in ESR and CRP are more profound.103 In psoriasis, all turmeric formulations appear to reduce symptoms.104 However, more human studies are required to confirm the efficacy and determine optimal preparations and doses of curcumin on RDs. The gene discussed is CRP; the disease is rheumatoid arthritis.