ONS with high doses of vitamin E can reduce the release rate of pro-inflammatory molecules (interleukine-8, plasminogen-activator inhibitor 1, TNF-α and CRP), lower lipid peroxidation and superoxide production, and decrease the rate of atheromatosis.70–72 Patients with a diagnosis of inflammatory skin diseases in particular, like psoriasis, were shown to have low serum vitamin E levels.73 Nevertheless, studies examining vitamin E ONS in RDs have only used animal models to date. The gene discussed is CRP; the disease is psoriasis.