There was a significant correlation between BMD and patient’s age and age of diabetes diagnosis, IGF-1, HbA1c, and PTH, but only an increase in HbA1c level effectively predicted a decrease in BMD.19 In 2011, J Feber et al. studied the effect of glucocorticoid in patients with nephrotic syndrome on bone age and bone density. This evidence concerns the gene IGF1 and nephrotic syndrome.