IL5 and type IV hypersensitivity disease: Systemic corticosteroids can reduce symptoms of delayed hypersensitivity reactions.11 They have also been shown to block the effect of IL-5 on in vivo eosinophil accumulation.12 Relapses have also been identified in many case reports, after tapering or withdrawal of systemic steroids13, which further emphasizes their role in patients with DRESS syndrome.