Considering that human K562 cells were derived from a patient with CML, and the expression of both the normal Abl transcripts and the BCR-ABL fusion transcript decreased approximately ten-fold when the cells were induced to differentiate with hemin,17 we then established the inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in transgenic mice of BCR-ABL leukemogenesis. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.