Rapidly emerging studies suggest that Piezo1 plays a dominant regulatory part in the mechanical conduction of ultrasound and can obviously mediate ultrasonic stimulation of neurons, tumor cells, and osteoblastic cells to trigger downstream cellular signal processes; for example, activation of Piezo1 by ultrasound can regulate neuronal function, inhibit tumor growth, and promote osteogenesis [15–17], highlighting the importance of Piezo1 in brain function and ultrasonic signal transduction. The gene discussed is PIEZO1; the disease is neoplasm.