PIEZO1 and Alzheimer disease: Surprisingly, TMAS up-regulated the expression of Piezo1 in microglia in the hippocampus (DG and CA1: P < 0.001, Fig. 4C), but this up-regulatory effect of TMAS was prevented by GsMTx-4, an antagonist of Piezo1 (DG: P < 0.05; CA1: P < 0.01, Fig. 4C), and TMAS activated Piezo1 more significantly in the hippocampus of AD mice compared with in AD + TUS group (DG and CA1: P < 0.05, Fig. 4C).