Nevertheless, the mice in the LEH-CSPC + laser + FMD group could not produce remarkable levels of inflammatory factors in comparison to the LEH-CSPC + laser group, such as tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) (Fig. S22), although they could produce significant levels of inflammatory factors in comparison to the control groups, suggesting that the auxiliary effect on tumor suppression was mainly from cellular immune responses of activated CD8+ T cells. The gene discussed is TNF; the disease is neoplasm.