Since liver X receptor (LXR), a nuclear receptor, regulates the expression of genes involved in cholesterol efflux, including Abca1, Abcg1, and Apoe, in atherosclerosis and aged mice [28–31], we examined whether the LXR agonist, GW3965, promotes cholesterol efflux from spinal cord lesions. This evidence concerns the gene APOE and atherosclerosis.