METTL3 and bacterial infectious disease: However, bacterial infection increases m6A levels in nascent transcripts, in particular in transcripts related to histone modifications (Wu et al. 2020), and m6A may be involved in regulating the response to LPS, as both m6A reader and writer proteins (YTHDF2 and METTL3) have been shown to play a role in regulating the cell response to bacteria and cytokine production (Yu et al. 2019) (Feng et al. 2018).