77). In DN, there is an increased influx of spontaneously active nociceptors into the spinal cord, which enhances synaptic transmission, further amplifying nociceptive signaling in a process called central sensitization. Microglia exhibit a proinflammatory phenotype, although the exact form is unknown. These cells can release factors, such as brain-derived neurotrophic factor, that amplify nociceptive synaptic signaling within the spinal cord and contribute to mechanical pain-related hypersensitivity (78. 79). The gene discussed is BDNF; the disease is liver dysplastic nodule.