The positive effect of IM hCG administration, also were reported in Jan Tesarik et al. ‘s(2003)study (15) which was done in oocyte recipients who underwent GnRH agonist pretreatment down regulation, in Robab Davar et al.’s (2016) study (16) which was done in infertile women with at least 2 previous failed IVF cycle and thin endometrium (thickness <7 mm), and in Yanbo Du et al. ‘s(2016)study (17) which was done in women with endometriosis-associated infertility. This evidence concerns the gene GNRH1 and Infertility.