CD1a expression was comparatively less in lepromatous leprosy (LL) which was similar to the study conducted by Sieling et al. This weak expression of CD1a in lepromatous lesions was not because of the primary defect of the CD1 system itself, but there may be some local factors at the site of infection that may be responsible for the blockade of CD1a expression in lepromatous cells [6]. This evidence concerns the gene CD1A and infection.