MAPT and frontotemporal dementia: Hubs are thought to play an important role in cerebral networks because many edges connect with this subset of nodes, and this network of highly connected ‘rich-club’ nodes may play a relatively important role in cognitive functioning.60 Significant loss of hubs has been observed in functional networks of clinically defined FTD patients, particularly in frontoinsular regions that may serve as epicentres in some patients.62 We observed here that roughly equal proportions of hubs identified in HC are lost in FTLD-tau and FTLD-TDP.