Among the IL-1 family cytokines and receptors, it has been observed that only IL-18 is associated with sporadic ALS, whereas the serum levels of the cytokines IL-33 and IL-36 and the soluble receptors sIL-1R2 and sIL-1R4 were comparable between ALS patients and healthy controls, and IL-1β, IL-1Ra and IL-37 were below detection (156). This evidence concerns the gene IL1B and amyotrophic lateral sclerosis.