IL18 and amyotrophic lateral sclerosis: The possible pathogenic role of IL-18 in ASL has been also recently underlined by a Whole Genome Sequencing study, which identified a genetic variant in a noncoding region of the gene encoding the IL-18 receptor accessory protein (IL18RAP) able to reduce mRNA stability and motor neuron neurotoxicity, thereby decreasing 5x the risk of developing ALS (157).