Microglia-specific deletion of the gene encoding the NFκB regulatory protein A20 leads to microglial cell proliferation, susceptibility to LPS-induced inflammation and increased EAE severity, reversed by NLRP3 or caspase-1 genetic deletion (125), indicating a critical role of microglia in MS, mediated by inflammasome activation. This evidence concerns the gene NLRP3 and myeloid sarcoma.