We recently reported that ICRP induces characteristics related with endoplasmic reticulum (ER) stress such as autophagosome formation, translocation of ER chaperones to the cell surface, and eIF2a phosphorylation (P-eIF2a) (Almanza et al., 2019[1]) in cervical and breast cancer (Martínez-Torres et al., 2020[25]; Reyes-Ruiz et al., 2021[33]). The gene discussed is EIF2A; the disease is breast cancer.