NOG and craniosynostosis: Of note, for the mouse skull, application of the BMP inhibitor Noggin has been shown to rescue RA-induced craniosynostosis (66), pointing to mineralizing-promoting effects of both RA and BMP, contrasting their opposite effects during FOP and consistent with our data revealed here for the developing zebrafish vertebral column, but with a function of BMP downstream of RA that is opposite to the order revealed here for the zebrafish vertebral column.