And NDUFB8 participate in the constitute of mitochondrial respiratory chain complex I. Lots of researches revealed the NDUFB8 is a potential target in many kinds of human tumors, such as cervical cancer tissue, gastric cancer, breast cancer, colorectal cancer, nasopharyngeal carcinoma and glioblastoma (65–70), nevertheless, no study explored the relationship between the NDUFB8 and pancreatic cancer. This evidence concerns the gene NDUFV1 and familial pancreatic carcinoma.