EPHX2, ACSF2, CYP27A1, ACSS1, and ALDH1L1 showed hypermethylation in several types of human cancer; on the contrary, AKR1B10, POLG2, NDUFB8, ACACB, and MRPS22 consistently showed hypomethylation in several types of human cancer. The gene discussed is MRPS22; the disease is cancer.