And NDUFB8 participate in the constitute of mitochondrial respiratory chain complex I. Lots of researches revealed the NDUFB8 is a potential target in many kinds of human tumors, such as cervical cancer tissue, gastric cancer, breast cancer, colorectal cancer, nasopharyngeal carcinoma and glioblastoma (65–70), nevertheless, no study explored the relationship between the NDUFB8 and pancreatic cancer. The gene discussed is NDUFV1; the disease is breast carcinoma.