The top five ZSCAN18-related hub genes (KDM6B, KAT6A, KMT2D, KDM1A, and HSPBP1) identified by PPI network analysis based on the CytoHubba plugin of Cytoscape (Figure 7A; Table S10) were abnormally regulated in BC and associated with OS, as determined with the bc-GenExMiner mining tool and Kaplan–Meier plotter (Figures 7B, C). The gene discussed is KMT2D; the disease is breast cancer.