A meta-analysis involving lean (BMI ≤ 23) and obese (BMI ≥ 23) PCOS patients identified ZBTB16, FSHR, GATA4 and AR to be downregulated in cumulus cells of lean PCOS women, while INSR, THADA, PLGRKT were downregulated in endometrial tissues of obese women with PCOS (27). The gene discussed is THADA; the disease is polycystic ovary syndrome.