HMGA2 has been associated with polycystic ovary morphology (PCOM) phenotype in PCOS patients of Han Chinese ancestry, potentially functioning to promote the proliferation of ovarian granulosa cells via the HMGA2/IMP2 pathway, thereby underpinning the increased proliferation of early-growing follicles and decreased apoptosis in granulosa cells in PCOS (35–37). Here, HMGA2 is linked to polycystic ovary syndrome.